What are the biggest differences between a twin pregnancy and a singleton pregnancy? Here are the Top 5 based on my personal experience: Ultrasounds – With the twins I would have an ultrasound every month and then every two weeks near the end of the pregnancy. I had at least 10 ultrasounds, maybe even more. My singleton pregnancy I had 2 ultrasounds. Third Trimester – Not a big surprise, but getting around with twins was much harder during the third trimester….